Genetic variation among African Americans

Gene Expression
By Razib Khan
May 5, 2010 5:43 PMApr 12, 2023 7:50 PM

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There’s new paper in Genome Biology (tip: Dienekes) which doesn’t present too much in terms of new results, Characterizing the admixed African ancestry of African Americans, but has really, really, good visualization of the data: Results From cluster analysis, we found that all the African Americans are admixed in their African components of ancestry, with the majority contributions being from West and West-Central Africa, and only modest variation in these African-ancestry proportions among individuals. Furthermore, by principal components analysis, we found little evidence of genetic structure within the African component of ancestry in African Americans.

Conclusions These results are consistent with historic mating patterns among African Americans that are largely uncorrelated to African ancestral origins, and they cast doubt on the general utility of mtDNA or Y-chromosome markers alone to delineate the full African ancestry of African Americans. Our results also indicate that the genetic architecture of African Americans is distinct from that of Africans, and that the greatest source of potential genetic stratification bias in case-control studies of African Americans derives from the proportion of European ancestry.

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