How Pig Guts Became the Next Bright Hope for Regenerating Human Limbs

A remarkable substance 
extracted from pigs enables the body to 
regenerate lost tissue, including fingertips and big chunks of muscle. And that may not be all it can do...

By Adam Piore and Scott Lewis
Sep 26, 2011 12:00 AMApr 6, 2023 6:50 PM

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The strange sensation in his right thigh muscle began as a faint pulse. Slowly, surely, it was becoming more pronounced. Some people would have thought it impossible. But Corporal Isaias Hernandez could feel his quadriceps getting stronger. The muscle was growing back.

When he first arrived in the trauma unit of San Antonio’s Brooke Army Medical Center in December 2004, Hernandez’s leg looked to him like something from KFC. “You know, like when you take a bite out of the drumstick down to the bone?” Hernandez recalls. The 19-year-old Marine, deployed in Iraq, had been trying to outfit his convoy truck with a makeshift entertainment system for a long road trip when the bomb exploded. The 12-inch TV he was clutching to his chest shielded his vital organs; his buddy carrying the DVDs wasn’t so lucky. 

The doctors kept telling Hernandez he would be better off with an amputation. He would have more mobility with a prosthetic, less pain. When he refused, they took a piece of muscle from his back and sewed it into the hole in his thigh. He did all he could to make it work. He grunted and sweated his way through the agony of physical therapy with the same red-faced determination that got him through boot camp. He even sneaked out to the stairwell, something they said his body couldn’t handle, and dragged himself up the steps until his leg seized up and he collapsed.

Generally people never recovered from wounds like his. Flying debris had ripped off nearly 70 percent of Hernandez’s right thigh muscle, and he had lost half his leg strength. Remove enough of any muscle and you might as well lose the whole limb, the chances of regeneration are so remote. The body kicks into survival mode, pastes the wound over with scar tissue, and leaves you to limp along for life.

For Hernandez, it had been three years and there was no mistaking it: He had hit a plateau. Lately the talk of amputation had cropped up again. The pain was constant, and he was losing hope. Then his life took another radical turn. He saw a science documentary on the Discovery Channel (no relation to this magazine) that told the story of a war veteran in Cincinnati named Lee Spievack whose fingertip had been severed by the propeller of a model airplane. Spievack’s brother, a surgeon in Boston, had sent him a vial of magic powder—the narrator called it “pixie dust”—and told him to sprinkle it onto the wound. Lee was to cover his hand with a plastic bag and reapply the powder every other day until his supply ran out. After four months, Lee’s fingertip had regenerated itself, nail, bone, and all.

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