These Lab-Grown Snake Organoids Produce Real Venom

Oozing with poison and small enough to fit in a petri dish, the organoids could one day help provide sorely-needed antivenoms.

By Leslie Nemo
Jan 23, 2020 8:45 PMJan 24, 2020 7:47 PM
Puff Adder
A puff adder, one of the nine species the researchers created venom gland organoids from. (Credit: EcoPrint/Shutterstock)

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Friday afternoons are reserved for free-for-all experiments in Hans Clevers’ lab. He lets his students at the Hubrecht Institute in the Netherlands test out their fun ideas — which is why no one told him about the poison-producing snake glands until after they were alive and well in the lab petri dishes. 

Called organoids, the collection of tiny poison glands proliferating in the lab were grown from cells from nine different snake species. The organoids, described today in a new report published in Cell, seemed frivolous at first. But the more Clevers, a molecular geneticist, learned about the challenges of snake bite research, the more he realized how useful these poison-generating life forms could be.

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