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Stem cells produce new tissues by recruiting executioners to damage their DNA

Discover how caspase-3 and CAD orchestrate DNA damage for stem cell differentiation, a vital process in tissue development.

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All of our cells are staffed by armies of executioners. They are usually restrained but when unleashed, they can set off a fatal chain reaction that kills the cell. This suicide squad does away with billions of cells every day. It helps to balance the production of new cells with the loss of old ones, to sculpt growing tissues and to destroy potential cancer cells.

But a new study suggests that the executioners aren't always lethal. In fact, they're essential for life. Through the unorthodox method of damaging our DNA, they can actually activate important genes. This technique for switching genes on is new to science but it's apparently vital for allowing some types of stem cell to produce new types of tissue.

Stem cells are bundles of untapped potential, with the ability to produce hundreds of specialist cells across the body. This process is called differentiation. Its details vary ...

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