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(pre)Historical genetics still has to be historical

Explore Tibetan Plateau population genetics, uncovering ancient migration and adaptation to high altitude over millennia.

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Credit:Albozagros

The genetics and history of Tibet are fascinating to many. To be honest the primary reason here is elevation. The Tibetan plateau has served as a fortress for populations who have adapted biologically and culturally to the extreme conditions. Naturally this means that there has been a fair amount of population genetics on Tibetans, as hypoxia is a side effect of high altitude living which dramatically impacts fitness. I have discussedpaperson this topicbefore. And I will probably talk more about it in the future, considering rumblings at ASHG 2012. But to understand the character of the effect of natural selection on a population it is often very important to keep in mind the phylogenetic context. By this, I mean that evolutionary processes occur over history, and those historical events shape the course of subsequent of phenomena. Concretely, to understand how the Tibetans came to be adapted to high altitudes ...

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