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Following Lewis and Clark’s Trail of Mercurial Laxatives

Ridden with gastrointestinal problems as they trekked across the continent, the Corps of Discovery was a big fan of popping mercury pills. Present-day archaeologists are still searching for evidence of the element in their excrement.

ByMarisa Sloan
Lewis and Clark At The Mouth Of The Columbia River, drawn by Frederic Remington in 1906. Behind the explorers is Sacagawea with her baby and husband.Credit: Everett Collection/Shutterstock

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In May of 1804, Captain Meriwether Lewis, Lieutenant William Clark and the rest of their 33-member Corps of Discovery began a long trek from St. Louis to the Pacific Ocean. Their goal? To explore the unknown territory and establish trade with the Native Americans.

“There’s something about the psychology of the audacious attempt to cross a continent, when they didn’t even know where they were going,” says Julie Stein, a geoarchaeologist at the University of Washington and executive director of the Burke Museum.

It’s true — the historical journey of Lewis and Clark has captured countless minds for more than 200 years, many of whom wish to reconstruct that journey themselves. To attempt just that, experts and enthusiasts alike rely on the duo’s military guidebook, journals, maps and … poop.

The Corps brought dozens of medicines with them, most of which induced either sweating, vomiting or defecating. Among the most ...

  • Marisa Sloan

    Marisa is an assistant editor at Discover. She received her master’s degree in health, environment & science reporting from Northwestern University’s Medill School of Journalism. In a previous life, while earning a chemistry degree from UNC Greensboro, Marisa worked to prolong the therapeutic power of antitumor agents. Ask her about enzymes!

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