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Eternal Sunshine of the Spotless Slug

Researchers have found a way to erase a memory in sea slugs, revealing insights into long-term memory mechanisms.

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In a creature much simpler than a human, scientists have figured out how to erase a memory. Sea slugs that had received repeated electrical shocks learned to expect them again--until researchers gave the slugs an injection that returned them to blissful ignorance.

The fellow above is Aplysia californica, a hefty sea slug that's shown here releasing its mysterious magenta ink. (I suppose that makes it an honorary inkfish?) Researchers at UCLA used a tankful of these quarter-pound slugs to test the hypothesis that a certain molecule allows the slugs to store long-term memories.

At the beginning of the experiment, researchers tested the slugs' baseline sensitivity by poking them in the hind end with a broom bristle. This causes a slug to retract its siphon, a straw-like structure near the tail, for a second or two. Then they "trained" the slugs by giving them five sets of electrical shocks to the ...

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