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Discover Dialogue: Sydney Brenner

The problem of biology is not to stand aghast at the complexity but to conquer it’

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In 1953, a few weeks after James Watson and Francis Crick discovered the shape of DNA and forever changed biology, Sydney Brenner, a young South African, arrived in England. Later he moved into their work space at the famed Cavendish Laboratory at Cambridge University. Brenner soon became one of the great pioneers of molecular biology, working with Crick to tease out the basics of how genes work.

In the decades that followed, Brenner helped launch the concept of using complex model organisms to figure out how genes function. In 2002 he won the Nobel Prize in Physiology or Medicine for his work in discovering the genetics of cell development by using the roundworm Caenorhabditis elegans. At age 77, he continues to actively run labs from La Jolla, California, where he is a Distinguished Research Professor at the Salk Institute.

You have been at this molecular biology thing for more than ...

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