Africa's genetic diversity revealed by full genomes of a Bushman and a Tutu

Not Exactly Rocket Science
By Ed Yong
Feb 18, 2010 12:00 AMNov 5, 2019 2:06 AM

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Meet !Gubi, the tribal elder of a group of Bushmen (or Khoisan), one of the oldest known human lineages. He lives the life of a hunter-gatherer in the Namibian part of the Kalahari Desert. But he also has a strange connection to James Watson, the [strike]British[/strike] American scientist who helped to discover the structure of DNA. For a start, they're both around 80 years old. But more importantly, they are two of just 11 humans to have their entire genomes sequenced.

Along with Archbishop Desmond Tutu, !Gubi is one of two southern Africans, whose full genomes have been sequenced by Stephan Schuster and an international team of scientists . Schuster's team also analysed the genes of three other Bushmen - G/aq'o, D#kgao and !Aıˆ (see footnote for pronunciation guide) - focusing on the parts of their genome that codes for proteins. Like, !Gubi, these men are tribal elders and all are around 80 years old. Despite the fact that the four Bushmen come from neighbouring parts of the Kalahari, their genetic diversity is astounding. Pick any two and peer into their genomes and you'd see more variety than you would between a European and an Asian.

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