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The Brain: The Connections May Be the Key

Once we model the connectome—the million 
billion points of contact between neurons in 
the brain—we’ll glimpse the anatomy of the mind.

3-D reconstruction of part of three neurons, generated from a stack of images of the mouse cortex.R. Schalek, B. Kasthuri, K. Hayworth, J. Tapia, J. Lichtman/Harvard and D. Berger, S. Seung/MIT

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If I didn’t know Sebastian Seung was a neuroscientist, I would have pegged him as a computer game designer. His onyx-black hair seems frozen in a windstorm. He wears black sneakers, jeans, and a frayed bomber jacket over an untucked shirt covered in fluorescent blobs. If someone had blindfolded me on Vassar Street in Cambridge, Massachusetts, led me into Building 46 on the campus of MIT, past the sign that says Department of Brain and Cognitive Science, taken me up in the elevator to the fifth floor and whisked off the blindfold in Seung’s lab, I still wouldn’t have guessed he had anything to do with brains. There are no specimens floating in jars on the shelves. There are no electrodes plugged into the heads of sea slugs. Instead, I see a dozen young men gazing at monitors, some pushing their computer mice, others drawing tethered pens across digital tablets ...

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