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The Best Brain Model Yet

Scientists grow a 3-D "brain" on a sponge-like scaffold.

By Katie Bo Williams
Nov 26, 2014 6:00 AMNov 15, 2019 9:21 PM
The doughnut sustains neurons (above) for months, longer than any other brain model. | David Kaplan/Tufts University


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One little doughnut — a lab-engineered protein doughnut — could help researchers cure Alzheimer’s and Parkinson’s and restore a traumatized brain. In August, scientists at Tufts University unveiled a new 3-D human brain “doughnut” model that accurately imitates brain function and injury response.

These multicolored protein ring doughnuts mimic brain regions. | David Kaplan/Tufts University

David Kaplan and his team built their model by constructing a collagen gel-filled protein ring that cultures rat neurons. Unlike older, simpler models, this one’s compartmentalized architecture (indicated by the multicolored rings) simulates the regions of the brain, and the chemically neutral protein allows neurons to connect realistically.

After growing the model for two months — previous ones lasted a few weeks at best — the team dropped different weights on the system to simulate brain trauma, like a concussion. Amazingly, all measured responses mimicked a human brain, making it the most realistic, responsive 3-D human brain model to date. And its longevity will allow researchers to introduce diseased cells to the model to better understand how brain diseases play out over time.

Although it’s impressive, the model has limitations. It absorbs oxygen and nutrients through cell membranes, not blood vessels, shortening its life span. Researchers want to integrate a humanlike vascular component to “feed” the model and extend its already superior life span.

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