I have my answer ("yes, but not by finding meaning `out there' in the world"), which I hope to write about more soon. In the meantime, listen to a great conversation between philosophers Owen Flanagan and Alex Rosenberg from Philosophy TV. "What there is, and all there is, are bosons and fermions."
Both discussants have written really good books. Rosenberg recently came out with The Atheist's Guide to Reality: Enjoying Life Without Illusions, while I very much enjoyed Flanagan's earlier book The Really Hard Problem: Meaning in a Natural World. Empirically, of course, naturalists often lead very enjoying and fulfilled lives. Here's a great profile of newly minted Laureate Brian Schmidt, in his capacity as a cook and winemaker as well as an astronomer. And here's Bob Kirshner, writing to the NYT from Friendship, Maine, about the meaning of dark energy.