Pigmentation loci, TPCN2 and ASIP

Gene Expression
By Razib Khan
Jun 26, 2008 11:48 PMNov 5, 2019 9:30 AM

Newsletter

Sign up for our email newsletter for the latest science news
 

Sandy pointed me to letter to Nature by a group which has done some earlier pigmentation work, Two newly identified genetic determinants of pigmentation in Europeans:

We present results from a genome-wide association study for variants associated with human pigmentation characteristics among 5,130 Icelanders, with follow-up analyses in 2,116 Icelanders and 1,214 Dutch individuals. Two coding variants in TPCN2 are associated with hair color, and a variant at the ASIP locus shows strong association with skin sensitivity to sun, freckling and red hair, phenotypic characteristics similar to those affected by well-known mutations in MC1R.

All well and good, but do note that in the fine print that it is the odds ratio for OCA2 really jumps out at you. Related:SLC24A5, SLC45A2, TYRP1, OCA2 and KITLG.

1 free article left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

1 free articleSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!

Subscribe

Already a subscriber?

Register or Log In

More From Discover
Recommendations From Our Store
Stay Curious
Join
Our List

Sign up for our weekly science updates.

 
Subscribe
To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2024 Kalmbach Media Co.