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Health

MAOA and violence

Gene ExpressionBy Razib KhanJune 10, 2009 7:35 PM

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The locus MAOA pops up every year or so in a study which attempts to correlate variation in these region with behavior. In particular, anti-social or pathological behavior. So another one is out, Monoamine oxidase A genotype is associated with gang membership and weapon use:

The low MAOA activity alleles conferred an increased risk of joining a gang and using a weapon in a fight for males but not for females. Moreover, among male gang members, those who used weapons in a fight were more likely to have a low MAOA activity allele when compared with male gang members who do not use weapons in a fight.

Here's a regression table which shows the main results:

gang1.jpg

This figure in particular is striking:

gang2.jpg

The MAOA variant is on the X chromosome, so obviously the genetic architecture is different for males and females (males have only one X). They didn't find much for females in this study. Another way to restate the study findings is that males with the low MAOA genotype MAOA genotype were 1.94 times more likely to be gang members, and they were 1.82 times more likely to have used a weapon in a fight. Cite:Monoamine oxidase A genotype is associated with gang membership and weapon use, Kevin M. Beaver, Matt DeLisi, Michael G. Vaughn and J.C. Barn, doi:10.1016/j.comppsych.2009.03.010

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