Frequent, Long-Term Blood Donation Could Reduce Risk for Blood Cancers

Scientists compared blood from frequent, long-term donors to that of more seldom ones and saw some key genetic differences in cell types.

By Paul Smaglik
Mar 18, 2025 9:45 PMMar 19, 2025 9:03 PM
Blood donations
(Image Credit: AnnaStills/Shutterstock)

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We give blood to save someone else’s life. It turns out that this altruistic act could also improve the donor’s health. But they might have to give a lot of blood over time for that effect.

A study screened 217 male volunteer blood donors. The researchers divided the group into two. One cohort had given blood over a hundred times during their lifetimes. The other group had done so less than five times.

Although the study was initiated in part to investigate whether long-term donation had any negative effects on the donors’ blood cells, they discovered an unexpected positive effect. Although both groups showed a good diversity of blood cell types, the frequent donors demonstrated some key differences, according to a study in the journal Blood.

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