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Health

CNTNAP2 & language

Gene ExpressionBy Razib KhanNovember 8, 2008 12:23 AM

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Anthropology.net & prefonal both have posts up which survey a new paper, A Functional Genetic Link between Distinct Developmental Language Disorders:

We found that FOXP2 binds to and dramatically down-regulates CNTNAP2, a gene that encodes a neurexin and is expressed in the developing human cortex. On analyzing CNTNAP2 polymorphisms in children with typical specific language impairment, we detected significant quantitative associations with nonsense-word repetition, a heritable behavioral marker of this disorder (peak association, P=5.0x10-5 at SNP rs17236239). Intriguingly, this region coincides with one associated with language delays in children with autism.

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