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Health

Are the HapMap samples representative?

Gene ExpressionBy Razib KhanMarch 5, 2009 12:56 AM

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Geographical Affinities of the HapMap Samples:

The CHB and JPT are readily distinguished from one another with both autosomal and Y-chromosomal markers, and results obtained after combining them into a single sample should be interpreted with caution. The CEU are better described as being of Western European ancestry than of Northern European ancestry as often reported. Both the CHB and CEU show subtle but detectable signs of admixture. Thus the YRI and JPT samples are well-suited to standard population-genetic studies, but the CHB and CEU less so.

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