Are B-Cells to Blame for Chronic Fatigue Syndrome?

The ravages of chronic fatigue syndrome may be the result of an overlooked but essential part of the body's own immune system.

By Jill Neimark
Apr 3, 2013 5:00 AMNov 12, 2019 5:38 AM

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Chronic fatigue syndrome’s debilitating symptoms might be the result of overzealous immune cells. | Piotr Marcinski/Shutterstock

Myalgic encephalomyelitis, or chronic fatigue syndrome, is a perplexing disorder that may seem more like a voodoo hex than an illness. Patients might lie bedridden in dark rooms, in chronic pain, often with multiple neurological symptoms like muscle pain, sweating and dizziness. 

Doctors have targeted various causes, from herpes viruses to retroviruses to depression. But a surprising new explanation suggests that the disorder is an autoimmune disease of the nervous system caused by overactive B-cells, which are normally responsible for churning out pathogen-killing antibodies.

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