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Elephants and humans evolved similar solutions to problems of gas-guzzling brains

Discover how aerobic energy metabolism genes in elephants and humans reflect evolutionary adaptations to energy demands of large brains.

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At first glance, the African elephant doesn't look like it has much in common with us humans. We support around 70-80 kg of weight on two legs, while it carries around four to six tonnes on four. We grasp objects with opposable thumbs, while it uses its trunk. We need axes and chainsaws to knock down a tree, but it can just use its head. Yet among these differences, there is common ground. We're both long-lived animals with rich social lives. And we have very, very large brains (well, mostly).

But all that intelligence doesn't come cheaply. Large brains are gas-guzzling organs and they need a lot of energy. Faced with similarly pressing fuel demands, humans and elephants have developed similar adaptations in a set of genes used in our mitochondria - small power plants that supply energy to our cells. The genes in question are "aerobic energy metabolism (AEM)" ...

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