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Everything Worth Knowing About ... Ancient DNA

The lure and limitations of a coded past.

By Bridget Alex
Jun 19, 2017 12:00 PMApr 9, 2020 11:13 PM
Ancient DNA Strand
(Credit: Art Tools/Shutterstock)

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In 1984, geneticists recovered 229 base pairs of genetic code from a quagga, a subspecies of zebra extinct since the late 1800s. The achievement proved DNA could survive in dead things and spurred a new field of science: paleogenetics. Today, technological advances allow scientists to read billions of letters from the genomes of ancient humans and other organisms, transforming our view of history and evolution.

The genetic record is “like a lost library ... and we’re just starting to learn the language of all those books that we have uncovered,” says Johannes Krause, director of archaeogenetics at the Max Planck Institute for the Science of Human History in Jena, Germany.

For anthropologists, ancient human DNA (aDNA) provides insights that could not be gleaned from fossils or artifacts. It’s already settled some major debates, including whether modern humans interacted with Neanderthals. Ancient genomes show definitively that our ancestors not only met, but mated with Neanderthals — multiple times — between 40,000 and 100,000 years ago.

In 2015, aDNA confirmed that Kennewick Man, an 8,000-year-old skeleton found in Washington state in 1996, was genetically closest to Native Americans. The revelation ended a 20-year legal battle and allowed tribes to rebury the bones.

A Quagga. (Credit: Florilegius/Alamy Stock Photo)
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