So far, humanity has caught a break with swine flu—despite spreading across the world and reaching pandemic status, it hasn't become a truly horrible killer like the 1918 "Spanish" flu. While there's a chance swine flu could return with a vengeance in the approaching flu season, many public health officials have another worry on their minds: that they never saw it coming in the first place. Swine flu cases came to worldwide attention in March and April, but the virus had been circulating in pigs for years and jumped to humans in late 2008. Can we be better prepared for the the next virus that threatens the health of all humanity?