Register for an account


Enter your name and email address below.

Your email address is used to log in and will not be shared or sold. Read our privacy policy.


Website access code

Enter your access code into the form field below.

If you are a Zinio, Nook, Kindle, Apple, or Google Play subscriber, you can enter your website access code to gain subscriber access. Your website access code is located in the upper right corner of the Table of Contents page of your digital edition.


World's Tiniest Scale Can Weigh Individual Molecules

Clever use of a microscopic resonator can quickly measure the masses of proteins and gold nanoparticles.

By Aline ReynoldsFebruary 10, 2010 6:00 AM
Caltech/Akshay Naik, Selim Hanay


Sign up for our email newsletter for the latest science news

Physicist Michael Roukes and his colleagues at Caltech have developed a microscopic device that can measure the mass of a single molecule in real time. Chemists use such sensitive weighings to help determine the chemical identities of unknown substances. The Caltech team says that its system could eventually allow scientists to analyze thousands of different proteins in a matter of milliseconds using much smaller samples than before.

The device, a microscopic resonator measuring 2 micrometers long by 120 nanometers wide, consists of a metallic layer 1 on top of a silicon carbide layer 2, attached to a silicon substrate 3 by minuscule supports 4. To “weigh” a molecule, a solution containing the molecule is sprayed onto the resonator. When a single molecule lands on it, it causes a change in the way the resonator vibrates. The resonator is connected to an electric circuit that registers the vibration change and transmits it to computers that then calculate the molecule’s mass. Each time a molecule lands on the resonator, it produces a mass measurement; eventually, hundreds of molecules can pile up on the resonator, allowing the scientists to obtain additional data for increased accuracy.

So far, Roukes has used this system to measure the masses of gold nanoparticles and three proteins found in the blood serum of cows. He is now working on a resonator that can vibrate in more complex ways, yielding even more precise readings.

    3 Free Articles Left

    Want it all? Get unlimited access when you subscribe.


    Already a subscriber? Register or Log In

    Want unlimited access?

    Subscribe today and save 70%


    Already a subscriber? Register or Log In