Leaky gut is a condition that occurs when holes or tears develop in the lining of the intestines. In order words, your gut is more permeable than it should be. This results in inflammation, which increases the risk of certain diseases.
Leaky gut can be caused by many different things, including stress, a poor diet, and weight issues. Others experience the condition because of poor gut microbiome. The good news is that there are many different supplements available on the market to help with leaky gut.
A quality leaky gut supplement will target the intestinal lining, restoring the lining and making it less permeable. A quality supplement will also improve and support overall gut health.
All supplements are unique, but most leaky gut supplements use natural ingredients, such as probiotics, in order to keep your gut health in tip top shape. But with so many products to choose from, it can be hard to know which ones are worthwhile.
Our guide covers all of the best leaky gut supplements of 2021.
Ranking the Best Leaky Gut Supplement Brands
There are dozens upon dozens of leaky gut supplement brands. Our team took the time to carefully review many of these products in order to provide a list of the top 10 best products. After much deliberation, here are the top 10 leaky gut supplements you’ll want to try:
1. Elm & Rye Probiotic 2. Amy Myers MD Leaky Gut Revive 3. Codeage Amen Leaky Gut+ 4. KaraMD® Vital Restore 5. HUM Flatter Me™ 6. biOptimizers Leaky Gut Guardian®
7. Seed Daily Synbiotic
8. Terra Origin Healthy Gut
9. Restore For Gut Health
10. Gundry MD Bio Complete 3
Unsure if you have a leaky gut? New to the world of supplements? If so, one of the best things you can do for your gut and overall health is to take a high quality, all-purpose probiotic like the one offered by Elm & Rye.
Probiotics not only help with digestion, Elm & Rye Probiotic contains ingredients that promote and support a healthy immune system. Elm & Rye is a transparent and ethical company, working to ensure customers are educated about the advantages of each of its products. This brand uses sustainably sourced ingredients and is committed to being more eco-friendly as a whole. In fact, Elm & Rye has committed to sustainable manufacturing and distribution processes as well.
This product is also quality-tested by an independent third party. This means that when you buy Elm & Rye’s Probiotic, you can buy with confidence knowing that the supplement includes pure and potent ingredients. There are no fillers or additives in this quality product.
Elm & Rye not only delivers a top-notch leaky gut supplement, but has perfected the art of quality customer support as well. The brand strives to develop long-term relationships with its customers. This means no shady marketing tactics or unproven claims.
As Elm & Rye says, its mission is to “to improve the lives of humanity by making high-quality supplements accessible and convenient.”
Gut feeling is everything, and Elm & Rye is one brand that you can trust from the pit of your stomach. With quality ingredients backed by independent testing, you’re sure to give your gut health the boost it needs.
A bottle of 30 tablets costs $50 and ships for free!
Amy Myers MD Leaky Gut Revive
Amy Myers MD Leaky Gut Revive is designed to target leaky gut and other digestive conditions using a variety of effective ingredients. Each serving contains well-known ingredients that promote digestive health, including L-glutamine, DGL, arabinogalactan, marshmallow root, slippery elm root, and aloe vera.
Together, these six ingredients work to support the gut lining while minimizing irritation and even ulcers.
A one-month supply costs $45, which is extremely affordable. What's also nice about this leaky gut supplement is that it's available in powder form. It's flavorless and can be added to your favorite drink.
Codeage Amen Leaky Gut+
Amen Leaky Gut+ offers the unique care that your gut needs in order to feel and work at its best. This supplement offers a combination of prebiotics, probiotics, L-glutamine, and zinc to support gut and digestive health.
It also contains other notable ingredients, including a fermented organic botanical blend made with organic apple cider vinegar, organic ginger root, and organic turmeric root.
Amen Leaky Gut+ is dairy, non-GMO, vegan and gluten free and is manufactured in a cGMP certified facility. The supplement is also third party tested for ingredient quality.
A month's supply costs $22.99. For best results, take three capsules daily with a glass of water.
KaraMD® Vital Restore
KaraMD® Vital Restore is a doctor formulated supplement that's designed to relieve leaky gut while also supporting a healthy microbiome. It gives the body the compounds it needs to naturally repair the mucous lining in the gut wall. The product may also boost mental clarity and mood while improving weight loss.
KaraMD® Vital Restore contains five powerhouse ingredients, including high doses of glutamine (1000mg) and berberine (500mg). Other active ingredients include turmeric, to minimize inflammation, as well as slippery elm and zinc.
This supplement is gluten free, vegan, and non-GMO. It's also made in the USA in a FDA-registered facility.
A month's supply costs $34.95. KaraMD offers a 10% discount when you buy three bottles, and a 20% discount when you buy four bottles. For best results, take three capsules a day with at least 8oz of water.
HUM Flatter Me™
Flatter Me™ is made with a blend of 18 full-spectrum ingredients, including digestive enzymes, that help the body break down food. This reduces bloating and improves digestion.
Flatter Me™ is non-GMO, gluten free, and contains no artificial sweeteners or colors. This supplement is also verified by independent labs for potency and is triple tested for purity.
Some of the top ingredients include ginger, peppermint leaf, fennel seed oil, protease, bromelain, lipase, and other compounds that are designed to assist in breaking down protein, fats, carbs, and fiber.
A month's supply costs $26, which is quite affordable. For best results, take one capsule twice a day, preferably between your two main meals.
biOptimizers Leaky Gut Guardian®
Leaky Gut Guardian® offers a powerful blend of probiotics and prebiotics, which work together to get rid of bad bacteria and promote the growth of good bacteria. This supplement also repairs the gut lining by reducing intestinal permeability.
Leaky Gut Guardian® also offers a host of other benefits, including eliminating bloating and gas, promoting overall GI health, reducing gut inflammation, and increasing nutrient absorption. You may even experience increased energy levels and improved immune response.
Leaky Gut Guardian® contains hyperimmunized egg powder along with a lactobacillus blend (10 billion CFU), including L. Rhamnosus, L. Gasseri, and L. Helveticus.
A month supply of biOptimizers Leaky Gut Guardian® costs $75.00. The subscribe and save program brings the price down to $62.25. Though a pricer option, this supplement contains highly effective ingredients for treating leaky gut.
This product is a powder and must be mixed in with 8oz of water. It's vanilla flavored and should be taken once a day on an empty stomach.
Seed Daily Synbiotic
Seed Daily Synbiotic is made with a 24-strain broad spectrum probiotic and prebiotic blend that is formulated to optimize gut, digestive, and immune health. It also offers systemic benefits to improve your overall health. Seed Daily Synbiotic contains a whopping 53.6 billion AFU!
This supplement supports digestive health by easing bloating, maintaining regularity, and alleviating occasional constipation. Seed Daily Synbiotic also works to improve gut barrier integrity and gut immune function.
What's unique about Seed Daily Synbiotic is that it uses a 2-in-1 nested capsule, with the outer capsule containing prebiotics and the inner capsule containing probiotics. This delivery method protects against digestion enzymes, stomach acids, and bile salts to ensure that 100% of the product is delivered to your colon.
Seed Daily Synbiotic is available at $49.99 for a month's supply. For best results, take two capsules, at the same time, daily. It's ideal to take this supplement on an empty stomach.
Terra Origin Healthy Gut
Terra Origin Healthy Gut is a supplement powder that was formulated to improve intestinal walls, strengthen the stomach lining, and tighten the digestive tract junctions to prevent leaky gut. This supplement aims to reverse all of the damage caused by bacteria and toxins, which can seep into the blood and wreak havoc on overall health.
Terra Origin Healthy Gut contains many of the top ingredients for gut health, including glucosamine, L-glutamine, zinc, licorice root extract, slippery elm bark powder, and marshmallow root. These ingredients work to build and repair the intestines and to decrease intestinal permeability. They also stimulate nerves to release mucus while reducing inflammation.
This supplement is available in a variety of delicious flavors, including Berry, Mint, Peach Banana, Matcha Green Tea, Honey Lemon, and Fennel.
A month's supply costs $25, which is extremely affordable. For best results, take one scoop mixed with water once a day.
Restore For Gut Health
Restore For Gut Health is a mineral supplement that can improve your health in many different ways. All of the ingredients have shown to be beneficial in balancing gut health as well as digestion, but that's not all! This supplement may also support respiratory wellness, promote immune function, enhance mental clarity, and even combat environmental exposures.
Restore For Gut Health explains that gut balance is vital to overall health. Diets that are high in gluten, processed foods, and GMOs can reduce bacterial health in the digestive tract. This in turn impacts gut, immune, and overall health.
This supplement uses Terrahydrite, a proprietary ingredient that supports intestinal wall integrity. This works to create a stable environment for good gut bacteria to grow and thrive.
One bottle contains a 60-day supply and costs $69.95. What's unique about Restore is that it's a liquid supplement. For best results, consume 1 teaspoon three times a day.
Gundry MD Bio Complete 3
Bio Complete 3 is marketed as the complete gut package. It contains a variety of ingredients that are designed to support gut and intestinal health. With a unique blend of potent probiotics, prebiotics, and revolutionary postbiotics, you're sure to notice a difference.
This supplement works by improving digestion and boosting the metabolism, which means you'll feel more energized and focused throughout the day. Bio Complete 3 may even curb cravings so that you don't fall prey for unhealthy junk food.
Bio Complete 3 is made with just three active ingredients, which include tributyrin, sunfiber, and bacillus coagulans. The supplement is formulated to be fast absorbing, ensuring that you truly feel the effects.
A month's supply costs $49.95. If you order multiple bottles at once, the per bottle price decreases. According to the manufacturer, for best results, take two capsules twice a day, preferably before eating.
How We Ranked
All leaky gut supplements claim to improve digestive health while also repairing leaky gut. But, not all supplements live up to their promises. Here’s how we determined which leaky gut supplements were quality and which ones weren’t.
Proven Ingredients: One of the most powerful ingredients that supports leaky gut repair is L-glutamine. In fact, multiple studies have confirmed that this compound can repair and restore intestinal and overall gut health. Because of this, supplements that contain L-glutamine were given the highest ratings.
Strong Dosages: In order to be effective, a supplement not only needs to contain the right ingredients, but those ingredients need to be offered at the right dosage. We avoided supplements that had micro-doses of L-glutamine and other plant and herbal extracts. While the ingredients list may look impressive, dosage is what really makes a difference in your gut health.
Scientific Evidence: Many leaky gut supplements haven’t undergone clinical trials or research. But some contain ingredients that have shown to be effective in promoting gut health. The more evidence you can find to confirm a certain ingredient, the better.
Ease of Use: Ease of use is really dependent on your own personal preference. Some leaky gut supplements require you to take multiple capsules a day. Others are available in powder form and can be mixed with water and drank while on the go. There’s no wrong or right delivery method, so we included various types of supplements.
Multiple Methods of Action: Leaky gut syndrome is a complicated condition. Quality leaky gut supplements are designed to target digestive and gut health from many different angles. Most of the top-rated supplements use a combination of probiotics, prebiotics, and other compounds to holistically support digestive health.
Manufacturer Reputation & Transparency: All-natural supplements, including those designed to repair leaky gut, are more popular than ever. This means that there are good and bad products on the market. When choosing a leaky gut supplement, we value clear ingredient profiles, transparent manufacturing standards, and proper dosages.
Advertised Benefits: Some leaky gut supplements make outlandish claims that seem too good to be true. You’ll find some products out there that guarantee to help you lose a lot of weight quickly, while others say that they’re designed to boost energy and cognition. Usually, the more outrageous the claim, the lower quality the product is. The best leaky gut supplements are those that advertise realistic, honest benefits.
Benefits of Leaky Gut Supplements
Leaky gut supplements can benefit gut health in many ways. Some of these products work by supporting digestion through the use of prebiotics and probiotics. These ingredients support the gut microbiome. Other leaky gut products offer high doses of plant and herbal extracts to repair and support gut lining.
Here is some of the scientific evidence in regard to leaky gut syndrome and the supplements designed to treat the condition.
According to Harvard Health, leaky gut is a condition that impacts gut permeability. Did you know that the intestinal lining contains 4,000 square feet of surface area? When the gut lining is working properly, it forms a tight barrier and is able to control what is absorbed into the bloodstream.
In simpler terms, your guts are the body’s first line of defense. They work to protect the body against harmful compounds that shouldn’t be absorbed.
The permeability of your gut can be affected by many different factors. No matter the cause, a weak and unhealthy gut lining can develop holes and cracks, which then causes leaky gut syndrome.
A leaky gut may allow toxins, partially digest food, and harmful bacteria to pass through the lining and into your bloodstream. This can cause indigestion and other digestive issues. Leaky gut even makes some people feel lethargic! Others lack physical and mental stamina, which causes brain fog and the inability to focus.
While many researchers dismissed leaky gut as a trendy internet topic, research has proven otherwise. There is now tons of scientific evidence that leaky gut is real. We’ve also learned a lot more details about the condition, including the causes, symptoms, and health risks of a leaky gut.
In fact, intestinal permeability plays a role in some of today’s most common gastrointestinal diseases, including irritable bowel syndrome, Crohn’s disease, and celiac disease.
What we don’t know (yet!) is how leaky gut syndrome impacts other parts of the body. Some studies have suggested that leaky gut may be connected to chronic fatigue syndrome as well as autoimmune disorders. Others have found a potential connection to other health conditions, including:
● Mental illness
A study conducted in 2020 found that “all disease begins in the (leaky) gut.” Researchers that conducted the study explored the idea that leaky gut could be the main culprit behind the epidemic of chronic inflammatory disease in the U.S. and other industrialized countries. Researchers also found studies that connected multiple diseases to loss of mucosal barrier function.
While we don’t know for sure what causes leaky gut syndrome, researchers have a few ideas. Most studies say that leaky gut is linked to eating processed foods, alcohol, and an overall unhealthy diet. Others have possibly linked certain prescription drugs as having ingredients that damage the intestinal lining.
A doctor cited by Harvard Health found that patients who experience leak gut often “improve significantly” by simply switching to a healthier diet.
However, there is still a lot to learn about leaky gut, its causes, and how it impacts the body overall. With more research being conducted, there is much hope that we’ll soon uncover some of the mystery behind this intestinal condition.
How do you help leaky gut?
One of the easiest ways to reduce leaky gut symptoms and to repair the intestinal lining is to remove problematic foods from your diet. This includes things such as processed foods, alcohol, and tobacco. Instead, you’ll want to infuse your diet with healthy foods such as fruits and vegetables.
A diet that’s rich in whole foods may support your intestinal lining as well as a leaky gut supplement will. Now is the time to switch to eating healthier foods so that you can restore your gut health.
Glutamine is one of the main compounds that can help with leaky gut syndrome. According to the Canadian Society of Intestinal Research, glutamine may promote gut mucosal integrity. Glutamine works like an energy source and is effective in preventing bacteria translocation. It fuels the immune system while also improving nitrogen balance, especially when the body is stressed.
Many studies have shown a connection between L-glutamine and leaky gut. Most researchers agree that the ideal dose ranges between 500mg to 1,500mg. At this dose, L-glutamine can benefit intestinal permeability.
Another compound that may benefit those with leaky gut is fiber. When eaten, fiber pushes waste outside of the body and supports regularity. According to Samaritan Health Services, eating a high fiber diet nourishes healthy bacteria in the gut. This is why it’s recommended to eat a diet that’s high in fruits, vegetables, whole grains, nuts, and legumes.
A study published in 2013 found that probiotics may protect and restore the gut barrier. Researchers analyzed several studies on probiotics and leaky gut and found that probiotics may be effective in treating and even possibly preventing certain conditions, including:
● Gluten intolerance
● Irritable bowel syndrome
● Inflammatory bowel disease
Recent research has also connected probiotics to mucosal immune function, barrier function, cell division, and apoptosis, which directly links intestinal permeability and leaky gut to these compounds.
Amy Myers, MD, the creator Leaky Gut Revive, which is one of the one of the top-ranked supplements on our list, recommends taking a highly-concentrated dose of probiotics (25 billion to 100 billion CFUs per day) to treat leaky gut. The company also recommends taking betaine hydrochloric acid (HCL), slippery elm, marshmallow root, and caprylic acid to improve leaky gut symptoms.
While we’ve learned a lot about leaky gut thus far, there is still plenty to learn and uncover. As new studies and research are conducted, we can expect to learn more about which compounds and supplements will help treat the symptoms and underlying cause of leaky gut.
Leaky Gut Supplement Dosages
All leaky gut supplements are different, and each one contains different ingredients at different dosages. This is why it’s important to follow the recommended dose provided on the supplement’s packaging.
Studies have found that L-glutamine is most beneficial when taken at doses between 500mg to 1,500mg. Ideally, you’ll want to choose a leaky gut supplement that offers a dose in this range. However, there’s still a lot more research to be done before a true standard dose can be recommended.
Despite what you may have read, colony-forming units (CFUs) aren't as important of a measure as you may think. In fact, a high number of CFUs (ie. 100 billion or more) may not benefit gut health. What’s most important is the quality of the probiotics that a leaky gut supplement contains, along with the delivery mechanism.
For example, a supplement that has two billion CFUs may actually deliver more active bacteria than a supplement with 50 billion CFUs. Delivery and quality matter!
Leaky Gut Supplement Side Effects
Like most natural supplements, those designed to treat leaky gut haven’t been linked to any significant side effects. When taken at the recommended dose, the risk of experiencing an adverse reaction is very low.
Similarly to other natural supplementation of products, such as collagen peptides, moringa, turmeric, green juices, sleep aids, prostate support, oral care, tinnitus relief or flat belly tonic recipes (see Meticore or Biotox), most supplements use high quality formulas. This means that ingredient quality is a top priority, along with purity, potency, and bioavailability for maximum results.
To prevent side effects when taking a leaky gut supplement, always follow the recommended dosage. You can also discuss taking this type of supplement with your doctor to ensure it won’t have a negative effect on your health.
FAQs About Leaky Gut Supplements
Q: What is a leaky gut syndrome?
A: Leaky gut syndrome is a broad term for any condition that impacts intestinal permeability.
Q: What causes leaky gut?
A: While there is no conclusive evidence, studies have linked many factors to leaky gut. Top factors include a poor diet, tobacco and alcohol use, as well as certain prescription drugs.
Q: Is leaky gut bad?
A: studies have shown that intestinal permeability plays a role in diseases such as celiac, Crohn’s, and others. There is also growing evidence that links leaky gut to other serious health conditions, though more research is needed to fully understand how the condition impacts overall health.
Q: What foods should I avoid to reduce leaky gut?
A: A wholesome diet is always best. Some medical experts suggest eliminating foods such as processed meats, gluten, wheat-based products, alcohol, junk food, artificial sweeteners, dairy products, carbonated beverages, and refined oils. Giving your body a break from these foods is a great option for healing a leaky gut lining.
Q: How long does it take to heal a leaky gut?
A: Recovery time varies and is highly dependent on the cause and overall condition of the gut. Experts believe that most people can improve their leaky gut within 2 to 12 weeks, though some conditions may be more or less severe.
Q: Does leaky gut cause indigestion, bloating, and other issues?
A:, These are all common side effects of leaky gut, but could also be symptoms of other digestive or intestinal issues
Q: How do leaky gut supplements work?
A: Leaky gut supplements work in many ways. A majority of these supplements contain probiotics, prebiotics, and herbal extracts to repair and support gut health. Others support the gut microbiome. And there are even supplements designed to reduce inflammation through the use of antioxidants.
Q: Can probiotics help with leaky gut?
A: Some studies have found that probiotics may help with leaky gut by making the intestinal tract work more effectively and efficiently. In fact, there are tons of leaky gut supplements that contain nothing but probiotics.
Q: Does leaky gut hurt my immune system?
A: Yes! In fact, a good percentage of your body’s immune system (ie. 70% to 90%) is in the digestive tract. This is why some leaky gut supplements claim to support immune health. But, further research is needed to verify the relationship between leaky gut and the immune system.
Leaky gut syndrome and other digestive health conditions continue to be a growing problem. While leaky gut syndrome was once dismissed as a fluke, studies have repeatedly shown that this condition is real. Research continues to emphasize the importance of gut permeability, especially when considering digestive function and immune system health.
If you believe you have a leaky gut or simply want to improve your gut health and microbiome, these are ten of the best supplements to take. When taken regularly, you can put gut disruption and dysfunction to an end!
● Elm & Rye Probiotic – Buy Today for Best Price Online
● Amy Myers MD Leaky Gut Revive
● Codeage Amen Leaky Gut+
● KaraMD® Vital Restore
● HUM Flatter Me™
● biOptimizers Leaky Gut Guardian®
● Seed Daily Synbiotic
● Terra Origin Healthy Gut
● Restore For Gut Health
● Gundry MD Bio Complete 3
Using one of these leaky gut supplements, you’ll not only improve your gut health, but your overall health as well.