Ed Yong has a post up on a behavior genetic publication where the sample size is 23. The researchers report a correlation between a SNP on the OXTR locus and "prosociality." To make a long story short the sample size suggested to Dr. Daniel MacArthur and Dr. Jospeh Pickrell that this was a spurious correlation. The bigger issue here is that there are functional reasons to assume that some genes are correlated with normal human variation in psychology and behavior, and a robust body of literature that these traits are heritable (trait value is highly predictive across relatives), but, the results associating a particular genetic marker with a given trait are much less robust. But I immediately realized something interesting: a sample size of 23 may be small, but there is a sample size potentially of thousands! I know my genotype at this SNP from 23andMe. How about some 23andMe customers get together and produce some results, and then get published in PNAS? A sample size of 230 would be easy I think, and you could probably push it much closer to 1,000.