25 Best Probiotic for Fibromyalgia in 2024

By Amber Smith
Jan 1, 2024 4:00 AMJan 1, 2024 6:50 PM
Elm Rye Probiotic


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The quest for effective remedies for fibromyalgia continues to drive scientific advancements and innovation in healthcare. Among the numerous potential solutions, probiotics have emerged as a promising avenue of exploration. In this era of breakthroughs, researchers have tirelessly examined the benefits of various probiotic strains, seeking those that may provide relief and improved well-being for individuals living with fibromyalgia.

This article delves into the top 25 probiotics that have garnered considerable attention and praise for their potential in alleviating fibromyalgia symptoms. Through extensive research and rigorous evaluation, experts have compiled a comprehensive list of these exceptional probiotics, each selected for its unique properties and potential to address the specific needs of those affected by fibromyalgia.

25 Best Probiotic for Fibromyalgia in 2023 

  1. Elm & Rye Probiotic 

  2. mindbodygreen probiotic+

  3. Jetson Probiotic for Weight Management

  4. Surebounty Probiotic for Men & Women

  5. Florastor Daily Probiotic Supplement for Women and Men

  6. Native Formulas Restore 3 Proteolytic Enzyme & Spore Probiotic Blend Supplement

  7. Probiotics for Women Digestive Health with Digestive Enzymes & Prebiotics

  8. Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement

  9. Ancient Nutrition Probiotics

  10. Hyperbiotics New Vegan Prebiotics Plus Probiotics for Women and Men

  11. Life-Space Shape B420™ Probiotics

  12. Ancient Nutrition Gut Health Supplement

  13. Ancient Nutrition Gut Health Supplement Leaky Gut Capsules


  15. Metagenics PhytoMulti Without Iron

  16. Gundry MD® Bio Complete 3

  17. Pure TheraPro Rx Power Probiotic 100B

  18. Doctor's Best Proteolytic enzymes

  19. Swanson Microlactin 500 Milligrams

  20. Balance ONE SerraDefend Biofilm Defense

  21. IBDassist™ - IBD Vitamins

  22. Align DualBiotic, Prebiotic + Probiotic for Women and Men

  23. Bulletproof Express 3-in-1 Probiotic

  24. Stonehenge Health Dynamic Biotics 

  25. Thorne FloraMend Prime Probiotic 

Fibromyalgia is a chronic disorder characterized by widespread pain throughout the body, along with other associated symptoms. It is considered a complex condition because it affects not only the musculoskeletal system but also the nervous system, leading to a range of physical and psychological symptoms.

The primary symptom of fibromyalgia is chronic, widespread pain that often affects the muscles, tendons, and ligaments. The pain is typically described as a dull ache, but it can also be sharp or throbbing. It tends to be more prevalent in specific tender points or trigger points located in various parts of the body.

In addition to pain, individuals with fibromyalgia often experience fatigue, sleep disturbances, and cognitive difficulties. These cognitive problems are commonly referred to as "fibro fog" and can manifest as memory problems, difficulty concentrating, and impaired decision-making abilities.

Other common symptoms of fibromyalgia include stiffness, headaches, irritable bowel syndrome (IBS), sensitivity to touch, temperature, and noise, as well as mood disorders like depression and anxiety. The severity of symptoms can vary from person to person and may fluctuate over time.

How can probiotics help with fibromyalgia?

The potential role of probiotics in fibromyalgia management is an area of ongoing research and investigation. While the precise mechanisms are not yet fully understood, several theories exist regarding how probiotics may offer benefits for individuals with fibromyalgia. Here are some ways probiotics might help:

Modulation of Gut Microbiota

Probiotics are live microorganisms that can help restore and balance the gut microbiota, which refers to the community of bacteria and other microorganisms residing in the digestive tract. Emerging evidence suggests that individuals with fibromyalgia may have alterations in their gut microbiota composition. By introducing beneficial probiotic strains, it is believed that the balance of gut bacteria could be positively influenced, potentially leading to improvements in symptoms.

Immune System Regulation

Probiotics have been shown to modulate immune responses, which could be relevant in fibromyalgia. Some studies have found that individuals with fibromyalgia exhibit signs of immune dysfunction, including increased inflammatory markers. By promoting a balanced immune response, probiotics may help regulate inflammation and potentially alleviate symptoms associated with fibromyalgia.

Reduction of Intestinal Permeability

Increased intestinal permeability, also known as "leaky gut," has been proposed as a potential factor in the development and progression of fibromyalgia. Probiotics may enhance the integrity of the intestinal barrier, reducing permeability and preventing the passage of harmful substances into the bloodstream. This could potentially alleviate systemic inflammation and contribute to symptom relief.

It is important to note that while there is growing interest in the potential benefits of probiotics for fibromyalgia, more research is needed to establish definitive evidence and determine the most effective probiotic strains, dosages, and treatment durations.

 1.     Elm & Rye Probiotic 

Elm & Rye's Probiotic supplement was specifically formulated to provide an additional boost to digestion for those in need. The recommended dosage for adults is one capsule per serving. Prior to usage, it is advised to consult with a healthcare professional, particularly if one is pregnant, nursing, has a suspected medical condition, or is currently taking any medications.

The intricate ecosystem of the gut is inhabited by trillions of bacteria, and their presence is vital for overall well-being. Notably, lactobacilli are recognized for their beneficial impact on gut health. These bacteria generate lactic acid, which may impede the colonization of harmful bacteria in the intestines. Additionally, they contribute to maintaining the integrity of the intestinal lining.

2.     mindbodygreen probiotic+

Designed to support a healthy gut, mindbodygreen’s probiotic+ features a unique blend of four probiotic strains.* While all strains are clinically tested to support a healthy gut, each one offers added benefits. For example, some strains promote regularity while others help ease bloat and maintain a healthy weight.* The shelf-stable probiotic has 30 servings in every bottle—each containing 32 billion CFUs of powerful probiotic bacteria. Save 15% on your order with code NEW15.

3.     Jetson Probiotic for Weight Management

Fit stands out with its impressive combination of 6 diverse probiotic strains, carefully selected to deliver powerful results. Among these strains is the extensively studied Bifidobacterium lactis B420, renowned for its potential in weight management. With a robust count of 17.5 billion colony-forming units (CFU), Fit equips you with the essential microbial support needed to enhance your energy levels, alleviate bloating, and lay the foundation for effective weight management.

4.     Surebounty Probiotic for Men & Women

Surebounty Probiotic was formulated to be an effective and reliable solution for both men and women. It contains 50 billion CFU of lactobacillus acidophilus, bifidobacterium lactis, bifidobacterium breve, and bifidobacterium longum in each capsule. 

5.     Florastor Daily Probiotic Supplement for Women and Men

Florastor, a trusted brand, offers essential support for digestive and immune health. This exceptional probiotic supplement works diligently to enhance the natural flora in the digestive tract, promoting a healthy balance while fortifying the immune system.

Each capsule of Florastor contains a potent 250mg dosage of their distinctive probiotic strain. Distinguished by its superior size and strength, this strain offers extended intestinal coverage and heightened protection compared to many other probiotics on the market. By delivering optimal support to the intestines, Florastor ensures that the body's digestive system operates at its best, contributing to overall health and well-being.

6.     Native Formulas Restore 3 Proteolytic Enzyme & Spore Probiotic Blend Supplement

Native Formulas Restore 3 Proteolytic Enzyme & Spore Probiotic Blend Supplement is a unique blend of probiotics and digestive enzymes that has been specifically designed to restore balance, support digestion, promote healthy gut bacteria, and improve nutrient absorption. The formula features 11 spore-forming probiotic strains, including Bacillus subtilis HU58®, which is a powerful probiotic that helps to maintain a healthy balance of intestinal microflora. 

7.     Probiotics for Women Digestive Health with Digestive Enzymes & Prebiotics

This powerful blend combines the benefits of 100 billion CFUs of probiotics sourced from 31 diverse strains, prebiotics, enzymes, a women's health blend, and essential multivitamins, providing a convenient and effective approach to optimize your gut health.

With high-potency probiotics, each shelf-stable bottle contains 90 capsules, ensuring an ample supply for your gut health journey. Each capsule boasts an impressive 50 billion CFUs, allowing you the flexibility to adjust the dosage according to your specific requirements. With this generous serving size, each bottle can last for up to 45 days or even longer, offering exceptional value for your investment.

8.    Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement

The perfect option for those looking to optimize their digestive health, Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement is a unique blend of 15 diverse enzymes. This supplement aids in digestion and increases the body’s natural ability to absorb essential vitamins and minerals from food. 

9.     Ancient Nutrition Probiotics

Ancient Nutrition Probiotics & Enzymes is a comprehensive gut health formula featuring 13 unique strains of probiotics along with digestive enzymes to help you maximize your nutrient absorption and improve digestion. Ancient Nutrition's proprietary blend includes three billion CFU per serving, providing an impressive dose designed to kickstart the digestive process right away. 

10.  Hyperbiotics New Vegan Prebiotics Plus Probiotics for Women and Men

Experience the power of 60 billion CFUs and 5 targeted probiotic strains with PRE+PRO! Did you know that a remarkable 80% of your immune system resides in your gut? By prioritizing the health of your gut microbiome, you can potentially support your immune system and maintain a consistent feeling of well-being.

11.  Life-Space Shape B420™ Probiotics

Life-Space Shape B420™ Probiotics with Prebiotics is a comprehensive solution for those looking to promote balanced digestive health. This supplement utilizes the renowned Bifidobacterium lactis, also known as B420, to enhance the digestion of dietary fiber and provide targeted relief from occasional digestive upset. With 10 billion CFU per serving and five complex prebiotic fibers, this product is a convenient and effective solution for those looking to fortify their gut health. 

12.  Ancient Nutrition Gut Health Supplement

Introducing a newly enhanced formulation designed to provide more precise and effective targeted support. This advanced formula seeks to support a healthy response to inflammation, promote optimal immune system function, alleviate occasional diarrhea, constipation, gas, and bloating, while also promoting healthy elimination, gut function, and a thriving gut microflora.

13.  Ancient Nutrition Gut Health Supplement Leaky Gut Capsules

Ancient Nutrition's Leaky Gut Capsules is a comprehensive blend of herbs, minerals, and vitamins specifically designed to promote balanced gut health. This potent formula features clinically studied ingredients such as marshmallow root extract, slippery elm bark powder, deglycyrrhizinated licorice root extract (DGL), zinc carnosine, and N-acetyl glucosamine to help ease occasional digestive discomfort, encourage a healthy immune response, and promote proper nutrient absorption. 


Start your day with a healthy gut and get your body in the best shape it can be! ROUNDHOUSE PROVISION's Morning Kick probiotic & prebiotic supplement helps give you an edge. This expertly crafted blend of 9 potent probiotics, paired with nourishing organic prebiotics, are designed to promote optimal digestion, immune health, and overall gut health. Perfect for anyone looking to take their wellness game to the next level. 

15.  Metagenics PhytoMulti Without Iron

Metagenics PhytoMulti Without Iron is the perfect supplement for those looking to support their optimal nutrition and wellness goals. This powerful combination of phytonutrients, vitamins, minerals, antioxidants, and probiotics helps to promote healthy cell function, a balanced immune system response, digestive health, and overall well-being. With its comprehensive formula that combines 23 essential vitamins and minerals, this supplement sets the stage for long-term health. 

16.  Gundry MD® Bio Complete 3

Gundry MD® Bio Complete 3 is the ultimate prebiotic, probiotic, and enzyme combo. Formulated by renowned cardiologist & nutrition expert Dr. Steven Gundry, this unique supplement contains 15 clinically-researched probiotics strains to help restore gut balance plus a powerful blend of digestive enzymes & prebiotics for maximum nutrient absorption. This formula is perfect for anyone looking to support their gut health and maximize the benefits of their healthy lifestyle. 

17.  Pure TheraPro Rx Power Probiotic 100B

Pure TheraPro Rx Power Probiotic 100B is an advanced dietary supplement that contains a clinically-studied strain of beneficial bacteria to help promote digestive health. This powerful blend combines the benefits of 10 billion CFUs sourced from 31 diverse strains, prebiotics, enzymes, and essential multivitamins. 

18.  Doctor's Best Proteolytic enzymes

Doctor's Best Proteolytic enzymes is an advanced formula designed to support digestive health and overall wellbeing. This unique blend features 10 different proteolytic enzymes that help break down proteins into their amino acid components, allowing for optimal absorption of nutrients for maximum benefits. 

19.  Swanson Microlactin 500 Milligrams

Swanson Microlactin 500 Milligrams helps support healthy joint function and mobility. This unique supplement features the powerful ingredient, Microlactin™, which is derived from the milk of cows raised in a pristine environment free from pollutants. With 500 milligrams per serving, this supplement helps reduce inflammation and supports natural joint lubrication for improved overall joint health.

20.  Balance ONE SerraDefend Biofilm Defense

Experience the transformative effects of SerraDefend as it supports your body's natural healing mechanisms. By promoting normal healing and repair processes, these systemic enzymes can contribute to overall well-being and vitality.

SerraDefend's potential in inhibiting biofilm production is also noteworthy. Biofilms are protective coatings formed by bacteria and other microorganisms, which can hinder the effectiveness of antibiotics and other treatments. By inhibiting biofilm production, SerraDefend helps your body combat potential threats and maintain a healthy microbial balance.

21.  IBDassist™ - IBD Vitamins

IBDassist™ is a comprehensive blend of vitamins and probiotics specifically formulated to help support those living with Inflammatory Bowel Disease (IBD). This formula utilizes cutting-edge ingredients, such as omega-3 fatty acids, Saccharomyces boulardii, and Slippery Elm Bark Extract to assist in maintaining proper digestive balance.

22.  Align DualBiotic, Prebiotic + Probiotic for Women and Men

For over 14 consecutive years, Align Probiotic has maintained its position as the top choice of Gastroenterologists, solidifying its reputation as the #1 recommended probiotic brand. This remarkable achievement can be attributed to its exceptional strain, which sets it apart from other probiotic brands in the market. Notably, Align Probiotic receives nearly twice the number of recommendations compared to any other probiotic brand, underscoring its unrivaled standing in the field of gastroenterology.

23.  Bulletproof Express 3-in-1 Probiotic

Experience the power of a healthy gut with Bulletproof Express 3-in-1 Probiotic. This unique formula combines cutting-edge probiotics, prebiotics, and enzymes to help encourage a balanced gut microbiome. The formula also features patented strains that have been clinically studied to support immunity and optimize digestion. Perfect for anyone looking to take their wellness routine to the next level. 

24.  Stonehenge Health Dynamic Biotics 

Stonehenge Health presents a groundbreaking product featuring 16 unique and clinically studied probiotic strains, carefully selected to provide optimal benefits. Among these strains are renowned names such as L. Acidophilus, L. Rhamnosus, B. Bifidum, and B. Longum, each bringing its own unique contribution to digestive health.

With a remarkable potency of 51 billion live Colony Forming Units (CFUs), this product stands as a leader in delivering superior probiotic support. These live cultures work in harmony to support the proper balance of the gut microbiome, fostering healthy digestion and potentially reducing common gastrointestinal discomforts such as constipation, diarrhea, gas, bloating, and acid reflux.

25.  Thorne FloraMend Prime Probiotic 

Thorne FloraMend Prime Probiotic is the ultimate probiotic supplement for those looking to support their digestive and immune health. Featuring a clinically-studied blend of 11 diverse probiotics, provide comprehensive coverage of the gut microbiome. The unique blend helps promote optimal digestion and absorption of key nutrients while also supporting healthy immune function. 

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