Why Antidepressants Are So Slow to Act

New information about "lipid rafts."

By Mallory LocklearDec 19, 2016 6:00 AM
Depression Mental Health - Shutterstock
(Credit: Igorstevanovic/Shutterstock)


Sign up for our email newsletter for the latest science news

Millions of Americans are prescribed antidepressants each year, yet it typically takes weeks for patients to feel any effects. Researchers could never explain the peculiarity, but new work published in July offers a clue.

The study, from researchers at University of Illinois at Chicago, examined rat brain cells and focused on lipid rafts — an area of the cell membrane that specializes in organizing important molecules. Previous studies showed that, in depressed patients, lipid rafts sequester a protein involved in cell signaling, called GαS, keeping it from doing its job.

Two protein receptors (yellow, red) float in a cell membrane’s lipid rafts (orange), which play a role in antidepressants’ delay. (Credit: Nicolle R. Fuller/Science Source)

The researchers administered an SSRI, a common type of antidepressant that’s thought to work by increasing the brain’s low serotonin levels. The new work shows the antidepressant appears to have other important effects. When administering SSRIs, the team saw that the drug first collected in the lipid rafts, and afterward, the critical GαS protein moved out of the rafts, freeing it up and making the protein more effective. This physical delay in the cells corresponded to the therapeutic delay of antidepressants.

Mark Rasenick, an author of the study and a physiologist at UIC, sees these findings as more than just an explanation for antidepressants’ lag time. He says he plans to use these findings to develop a test to help predict how patients will respond to an antidepressant.

1 free article left
Want More? Get unlimited access for as low as $1.99/month

Already a subscriber?

Register or Log In

1 free articleSubscribe
Discover Magazine Logo
Want more?

Keep reading for as low as $1.99!


Already a subscriber?

Register or Log In

More From Discover
Recommendations From Our Store
Shop Now
Stay Curious
Our List

Sign up for our weekly science updates.

To The Magazine

Save up to 40% off the cover price when you subscribe to Discover magazine.

Copyright © 2023 Kalmbach Media Co.