Register for an account


Enter your name and email address below.

Your email address is used to log in and will not be shared or sold. Read our privacy policy.


Website access code

Enter your access code into the form field below.

If you are a Zinio, Nook, Kindle, Apple, or Google Play subscriber, you can enter your website access code to gain subscriber access. Your website access code is located in the upper right corner of the Table of Contents page of your digital edition.


Obesity as part of normal human variation

Gene ExpressionBy Razib KhanAugust 21, 2009 6:00 AM


Sign up for our email newsletter for the latest science news

Common body mass index-associated variants confer risk of extreme obesity:

To investigate the genetic architecture of severe obesity, we performed a genome-wide association study of 775 cases and 3197 unascertained controls at 550 000 markers across the autosomal genome. We found convincing association to the previously described locus including the FTO gene. We also found evidence of association at a further six of 12 other loci previously reported to influence body mass index (BMI) in the general population and one of three associations to severe childhood and adult obesity and that cases have a higher proportion of risk-conferring alleles than controls. We found no evidence of homozygosity at any locus due to identity-by-descent associating with phenotype which would be indicative of rare, penetrant alleles, nor was there excess genome-wide homozygosity in cases relative to controls. Our results suggest that variants influencing BMI also contribute to severe obesity, a condition at the extreme of the phenotypic spectrum rather than a distinct condition.

As I'm sure you know, some traits, like pigmentation, are controlled by variation on a few genes, a half a dozen. For example, one locus, SLC24A5 controls 25-40% of the complexion variation between Europeans and Africans, and can account for he same proportion of complexion variation among South Asians. By contrast, variation in height is explained by genes of much smaller effect, excepting distinct phenotypes such as dwarfism. These data reiterate that though genes such as FTO are of particular interest in relation to variation in body mass index should probably be viewed as a quantitative trait, whereby the obese are simply at the "tail" of the distribution which emerges in response to a particular environment. This is what I mean (these are not real distributions!):


As you can see, simply changing the environment will result in an increase in the number who are defined as obese (BMI >= 30) as the tail of the distribution moves to the right.... Cite: Human Molecular Genetics 2009 18(18):3502-3507; doi:10.1093/hmg/ddp292

    3 Free Articles Left

    Want it all? Get unlimited access when you subscribe.


    Already a subscriber? Register or Log In

    Want unlimited access?

    Subscribe today and save 50%


    Already a subscriber? Register or Log In