Clever canines catch colon cancer cues contained in crap.



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Image: flickr/liz westWe have all heard about the wonders of dogs' noses: dogs are aware of many odors that we simply cannot detect. These scientists decided to try and harness this sniffing prowess for cancer detection... in poop samples! They used Labrador retrievers trained to detect cancer by smell, and had them sniff stool and breath samples from people with and without colon cancer. The dogs were incredibly accurate at identifying the samples from the cancer patients, suggesting that there is a common cancer "scent", and odor detection may prove to be a useful, non-invasive cancer test.Colorectal cancer screening with odour material by canine scent detection. "OBJECTIVE: Early detection and early treatment are of vital importance to the successful treatment of various cancers. The development of a novel screening method that is as economical and non-invasive as the faecal occult blood test (FOBT) for early detection of colorectal cancer (CRC) is needed. A study was undertaken using canine scent detection to determine whether odour material can become an effective tool in CRC screening. DESIGN: Exhaled breath and watery stool samples were obtained from patients with CRC and from healthy controls prior to colonoscopy. Each test group consisted of one sample from a patient with CRC and four control samples from volunteers without cancer. These five samples were randomly and separately placed into five boxes. A Labrador retriever specially trained in scent detection of cancer and a handler cooperated in the tests. The dog first smelled a standard breath sample from a patient with CRC, then smelled each sample station and sat down in front of the station in which a cancer scent was detected. RESULTS: 33 and 37 groups of breath and watery stool samples, respectively, were tested. Among patients with CRC and controls, the sensitivity of canine scent detection of breath samples compared with conventional diagnosis by colonoscopy was 0.91 and the specificity was 0.99. The sensitivity of canine scent detection of stool samples was 0.97 and the specificity was 0.99. The accuracy of canine scent detection was high even for early cancer. Canine scent detection was not confounded by current smoking, benign colorectal disease or inflammatory disease. CONCLUSIONS: This study shows that a specific cancer scent does indeed exist and that cancer-specific chemical compounds may be circulating throughout the body. These odour materials may become effective tools in CRC screening. In the future, studies designed to identify cancer-specific volatile organic compounds will be important for the development of new methods for early detection of CRC."

Related content: NCBI ROFL: Factitious diarrhea: a case of watery deception. NCBI ROFL: The chemistry of pig sh*t. NCBI ROFL: High Altitude Flatus Expulsion (HAFE). Seriously, science?: 3D interactive poop sculptures… you know, for kids!

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