Best Liver Supplements: Top Liver Health Detox Products 2021

A look into the best liver health supplements on the market for sale in 2021. Which are the top liver detox pills and liver cleansing products this year?

By Amber SmithSep 9, 2021 12:00 AM
Liver Supplement 1


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The liver is one of the body's main organs. Humans cannot survive without a functioning liver, and there are many diseases and illnesses that can weaken it. The liver is sensitive and can quickly become infected. Cancer can also affect the liver. Certain habits can impair the liver and make it more prone to infection and disease. Liver supplements can help keep the liver healthy. Here are some of the best liver health detox products available for purchase today

The Top 8 Best Liver Health Detox Products in 2021 

As multi-functional and vital to human health as the liver is, there are several very unique liver detox complexes that made the cut as the top-performing liver supplements to take if you are considering a natural cleansing of the liver. 

Our liver plays a major role in supporting our overall health, including helping with the metabolic process, digestion, and proper blood circulation, as well as cleansing the body of harmful toxins.    However, most people damage their livers without even knowing it, with things like drinking too much alcohol, eating processed or fried foods, or even being just a little overweight.    

That’s why many people have been turning to natural liver health supplements. A good quality liver supplement is an effective solution to help repair liver damage and optimize liver functioning.    

The most recognized liver health supplements from the best brands for detox and cleanse benefits are as followed for 2021: 

  • PureHealth Research Liver Health Formula 

  • Organifi Liver Reset 

  • Zenith Labs Zenith Detox 

  • 1MD LiverMD 

  • Live Conscious LiverWell 

  • Amy Myers MD Liver Support 

  • Gundry MD Complete Liver Support 

  • Advanced Bionutritionals Advanced Liver Support 

Let's review each of the best liver supplements for bodily detoxification and cleansing to see which one is the optimal choice for you. 

PureHealth Research Liver Health Formula  

PureHealth Research Liver Health Formula is the most recognized liver support supplement on the market in 2021 thus far. But is it just? Can the Liver Health Formula supplement not only help the liver fight off infection, inflammation, and disease, but also help improve your energy and appearance. It contains ingredients that can help boost your stamina and make your mind sharper. Dr. Holly Lucille, ND, who has been on Doctor Oz, FOX, TIME, CBS, ABC, NBC and The Doctors before, speaks highly of the Liver Health Formula by PureHealth Research in that it can "recharge your body's 'youth battery' for unlimited energy, a trim waistline, and sharp thinking." 

The well-respected PureHealth Research supplement brand formulated the Liver Health Formula to help give extra support towards unbalanced blood sugar levels, various metabolic disorders, heart and kidney issues, excessive bleeding or increased pressure in the brain and even weight gain. The product is gluten soy, and dairy free, and uses no GMO ingredients and is safe for vegans to consume too. There are seven major liver function enhancers the Liver Health supplement by Pure Health Research refers to on its official product page and is worth mentioning is a potent lineup of ingredients like turmeric, beet, dandelion, milk thistle artichoke extract, ginger and alfalfa. In the question to find the best liver health supplement, the Liver Health Formula offers one of the most potent products to be available for purchase today and can get one bottle for $44 or as low as $29 per for the best value on the official website

Organifi Liver Reset  

Organifi Liver Reset is one of the more popular liver health supplements, and it comes from a reputable brand. It contains artichoke leaf extract, Triphala, milk thistle, and dandelion root, considered superfoods for the liver. The ingredients are all organic and have been used to aid in liver health for centuries. It's also an affordable product with a 30-day supply costing less than $30. 

Zenith Labs Zenith Detox  

Zenith Labs Zenith Detox is designed to help with phase 1 and 2 detoxification. It contains Setria glutathione, L-methionine, and Schisandra berry extract and can help improve your stamina and give you a more youthful appearance. Of course, it also helps improve liver function and is less than $50 a bottle. Right away, the official Zenith Detox supplement for supporting liver health and phase one and two detoxification hits you with a "special god molecule" headline that talks about how one can understand the key to feeling young again and extend the prime of your life. The doctor-formulated liver health supplement for safe and effective cleansing benefits is made by Dr. Ryan Shelton and Zenith Labs is meant to target the root cause of free radical damage based on its highly absorbable form of 'fermented god molecule', Setria® Glutathione. On top of this impressive dose of 150mg of this unique extract, there is a glutathione-restoring blend and a rapid detox blend to make it the "Liver Support Blend" that helps give the body extra detox support for its "commander of detoxification." 

Here is a look at the actual ingredients and dosage of this liver supplement: 

Setria® Glutathione – 150mg 

Glutathione Boosting Blend 

  • N-acetyl-l-cysteine – 100mg 

  • L-Methionine – 300mg 

  • Schisandra Berry Extract – 50mg 

  • Picrorhiza Root Powder – 50mg 

  • Folic Acid – 100mcg 

Rapid Detox Blend 

  • Vitamin B6 – 25mg 

  • Vitamin B12 – 100mcg 

  • Magnesium – 50mg 

  • Dandelion Root Extract – 50mg 

  • Broccoli Sprout Extract – 50mg 

  • Green Tea Leaf Extract – 50mg 

  • Taurine – 50mg 

Liver Support Blend 

  • Milk Thistle Seed Extract – 150mg 

  • Choline Bitartrate – 200mg 

  • Beetroot Extract – 50mg 

  • Bupleurum Root Powder – 100mg 

  • Artichoke Leaf Extract – 100mg 

It ranks high up on the best liver health supplements list in comparison to the rest of the liver detox products due to its all-in-one detoxifying solution and the fact that Zenith Labs is such a highly respected company in the nutritional and dietary supplement industry for many years now. The quality, purity and safety of the Zenith Detox supplement for optimal liver health function by Zenith Labs is not in question given their flagship detoxification formula passes all the smell tests.  The price of the Zenith Labs liver health supplement is as low as $33 if you act now to save big on the official Zenith Detox website

1MD LiverMD  

1MD LiverMD is another popular liver supplement that you can find online and in many stores and pharmacies. It contains vitamins and minerals like zinc, vitamin E, and selenium. It also contains milk thistle extract, clinically proven to help improve liver function and fight liver disease. Price at $45 a bottle, it's an affordable way to help keep your liver healthy. 

In all, LiverMD delivers 6 powerful, clinically studied ingredients in one groundbreaking, exclusive 1MD formula to help purify and optimize liver function for better energy, metabolism, and overall health.  

This doctor-formulated liver support stands out because it includes EvnolMax, which is a clinical strength tocotrienol, and Siliphos, the bioavailable active ingredient in milk thistle. LiverMD is also made with zinc, selenium, and other ingredients that work to help detox and repair your liver.  

Additionally, 1MD offers a 90-day, risk-free, money-back guarantee, proving the company stands behind its products.   

Live Conscious LiverWell 


LiverWell’s formula combines optimal liver health ingredients, including clinically studied milk thistle, NAC, and alpha lipoic acid to name a few. Their product is shown to aid liver function, metabolism, and whole-body detoxification. LiverWell is best for those who need to reduce the effects of environmental toxins and struggle with metabolic issues.   

Live Conscious LiverWell not only helps protect your liver from diseases and infections, but it also helps improve your metabolism. Two capsules a day can allow you to enhance liver detoxification and protection while also supporting healthy immune cell production and a healthy metabolism. At $26 a bottle, it's packed full of vitamins to help nourish your liver and entire body. 

LiverWell’s use of powerful antioxidants has also been shown to reduce and repair damage done to liver and kidney health from free radicals in the body.  Beyond that, LiveWell offers a comprehensive 365-day return policy, so everyone can try their products completely risk-free.  

Amy Myers MD Liver Support  

The liver helps remove toxins from your body, and Amy Myers MD Liver Support is meant to help improve the detoxification process. Not only will it help your liver function properly and help fight disease, but it can also help boost your immune system. It contains alpha-lipoic acid that helps break down free radicals and is designed to optimize liver function. You can grab a bottle for just under $35. 

Gundry MD Complete Liver Support 


The fewer toxins in your body, the easier it is on the liver. Gundry MD Complete Liver Support doesn't just help boost liver function; it also helps with detoxification and can help strengthen the immune system. It defends the body against environmental toxins and reduces free radicals. It contains milk thistle, orange peel extract, and dandelion. You can buy it online or in stores for less than $20. 

Advanced Bionutritionals Advanced Liver Support  

Advanced Bionutritionals Advanced Liver Support is made to support your brain and liver health. It reduces inflammation in the body and contains many natural ingredients that have been proven to help increase liver function. The product is made in American, but all ingredients are sourced globally. You will find NAC, milk thistle, phosphatidylcholine, glycyrrhizin, and selenium in this supplement, and you can purchase a bottle for less than $40. 

What Are The Active Ingredients In Most Liver Supplements? 

Many different active ingredients are used in liver supplements and have been proven to help improve liver health. Here are some of the most common. 

Milk Thistle 

Milk thistle is a plant that has properties that can help improve liver health. It is named for the white veins that appear on the leaves of the plant. Research has shown that milk thistle can help treat some types of liver disease, such as cirrhosis. 

Artichoke Leaf 

The entire artichoke plant can be consumed, but the leaves are particularly good at treating liver problems. Artichoke leaf is often added to liver supplements to help reduce inflammation. 

Dandelion Root 

Dandelion root is often used to treat indigestion and other stomach problems. It can also help treat some common liver issues. When added to supplements, dandelion root can help prevent liver dysfunction, cirrhosis, hepatitis, liver disease, and cancer. 

Licorice Root 

Licorice root contains special enzymes that the liver needs to function correctly. When added to supplements, it can improve liver enzymes and halt liver alcohol-induced damage. 


Turmeric is excellent at improving liver health. It can protect the liver from oxidative stress by helping to control free radicals in the body. This means the liver has to work less to filter toxins. Turmeric can also reduce inflammation in the liver. 

Yellow Dock Root 

Yellow dock root has been used for many centuries and is often used to make tea. It is also a common ingredient in liver supplements. It helps with detoxification, so it can help the liver work less and more efficiently to filter free radicals through the body. 


Beetroot is full of antioxidants that the body needs to stay healthy. The liver thrives when there are plenty of antioxidants to help with purifying and detoxifying the body. Beetroot can help the liver regenerate and heal quickly too. 


Ginger has many essential nutrients that help heal the liver. Ginger is added to liver supplements to improve blood circulation and deliver oxygen, minerals, and vitamins to all cells in the body. 


Choline offers many benefits for the liver, and it is often used to treat hepatitis and cirrhosis. It helps reduce inflammation and can detoxify the liver to make it work better. 


Selenium is used to produce fatty liver, and when added to supplements, it can help the liver recover from disease and work more efficiently. It also helps to keep the liver working correctly and reduces the risk of severe liver diseases. 

What Are The Symptoms Of Early Liver Problems? 

Liver problems are sometimes hard to diagnose in the early stages. The symptoms of an infected or diseased liver can mimic those of other common illnesses that are not considered severe. If you are worried you could have liver problems and are experiencing any of these symptoms, see a doctor rule out liver problems. 


When the liver is not functioning correctly, it can lead to fatigue. The fatigue often gets worse as the disease or illness progresses, and in some cases, it can be severe. Weakness can also occur with fatigue or on its own. When the liver isn't working as it should, it can put stress on other organs. It can also allow for a build-up of toxins, which can cause fatigue as well. 

Loss Of Appetite 

Because the liver often swells when infected or diseased, it can press against the stomach and other organs and reduce a person's appetite. Many people find that loss of appetite is one of the first symptoms they experience with liver failure. This can also be a sign of gallstone or gallbladder problems which are often associated with liver disease. 

Nausea and Vomiting 

A person suffering from liver disease may feel nauseous and vomit regularly. Many people report feeling worse early in the morning or at night. Lying or sitting in different positions can make this symptom worse. Because nausea and vomiting can occur with many mild illnesses, these symptoms alone are not enough to alert the sufferer or motivate them to seek medical help. 

Discolored Urine and Stools 

The liver helps filter toxins and waste in the body, and when it's not functioning correctly, it can fail to do so. This can lead to bright yellow or green urine and dark grey stools. When the liver cannot filter the blood, toxins can travel through the digestive system and come out in urine and stools. 

Abdominal Pain 

Abdominal pain is a common symptom associated with liver problems. The liver can cause pain in the upper and lower abdomen. It can also cause pain around the ribcage. If the liver is swollen, it may press against other organs and cause pain throughout the body. The pain can range from mild to severe and can sometimes before confused with other medical problems, including constipation and appendicitis. 


Jaundice is a condition that leads to yellow eyes and skin. It occurs when there is a build-up of bilirubin, a yellow-orange bile pigment, in the body. It can be caused by liver infections, gallstones, and tumors. If left untreated, jaundice can lead to severe liver disease and an increased liver and gallbladder cancer risk. 

Leg and ankle swelling 

There are many toxins that the body needs to remove and prevent from the bloodstream. The liver works to do this. If the liver is not working correctly or problems in the body inhibit the toxins from making it to the liver to be filtered, it can cause severe health problems. When the lower legs or ankles swell, they can hold onto toxins. Once the swelling goes down, the toxins can travel to the body quickly and overwhelm the liver, leading to disease. 

What Are The Most Common Causes Of Liver Problems? 

Many different diseases and habits can lead to liver problems. Sometimes the cause of the problem can determine the severity of the issues. Here are some of the most common causes of liver problems. 


All types of hepatitis can lead to liver problems. Viral hepatitis attacks the liver and can weaken it over time. Some people can have hepatitis with very mild symptoms, making it hard to diagnose. While they may not be demonstrating signs, the liver could still be affected. Some of the common symptoms of hepatitis include, 

  • Jaundice 

  • Swelling in the feet and legs 

  • Bloody feces 

  • Bloody vomit 

  • Abdominal pain 

  • Flank pain 

Overdose of Over-the-Counter Products 

Many people think that over-the-counter medications are safe to take because they are so easy to obtain. While these medications have been proven to be safe, taking too many at a time or taking them for a long time can affect the liver. Any medications taken make their way through the liver, which acts as a filter. Because so many people take over-the-counter medications, this is one of the most common causes of liver problems. 

Long-term Excessive Alcohol Consumption 

Alcohol can damage the liver in a short time, and those who drink regularly are more at risk for cirrhosis and liver cancer. Alcohol weakens the liver and prevents it from functioning as it should. Alcoholic liver disease can eventually cause the liver to fail. The liver also can regenerate and heal if it is not too severely damaged. Those who only drink occasionally or stop drinking after periods of alcoholism can recover from liver problems. Supplements can help the liver heal faster. 


The liver does a lot of work in the body, and it requires the proper nutrients to function correctly. Malnutrition can prevent the liver from functioning and eventually cause liver failure. Malnutrition has multiple causes include, 

  • Extreme diet 

  • Eating disorders 

  • Lack of breastfeeding in children 

  • Mental health problems 

  • Conditions that prevent the body from absorbing certain nutrients 

  • Slow recovery from certain illnesses 

  • Poor quality of life 

  • Mobility issues and inability to prepare healthy meals 


Hemochromatosis occurs when too much iron builds up in the body. It can lead to many different problems, including diabetes, heart disease, and liver disease. It is caused by a mutation gene if left untreated. Symptoms of Hemochromatosis include, 

  • Memory fog 

  • Bronze or grey skin color 

  • Liver failure 

  • Heart failure 

  • Impotence 

  • Loss of sex drive 

  • Joint pain 

  • Diabetes 

  • Abdominal pain 

  • Weakness 

  • Fatigue 

How Are Liver Problems Treated? 

There are many different ways to treat liver disorders, and the treatment largely depends on the cause and type of illness. Here are some of the most common liver disease treatments. 

Lifestyle Modifications 

If the liver disease is not too advanced or is caught in the early stages, doctors may simply recommend lifestyle modifications to help patients recover. The liver can heal itself in many cases, and simple lifestyle changes can be enough to heal correctly. These lifestyle changes can include, 

  • Liver health supplements 

  • Diet changes 

  • Reducing smoking 

  • Reducing alcohol intake 

  • Exercise 

  • Prescription medication modifications 


Surgery can be used to treat some types of liver problems. If small portions of the liver are diseased or cancerous tumors are growing, surgery may be necessary. The liver can function with small pieces removed, so even though part of the liver may be missing, it can regenerate and work properly again. 


There are medications available to treat some types of liver disease. The medications can vary and are often prescribed for minor or moderate cases of liver disease. Medications are often prescribed alongside the suggestion of lifestyle change. If the medicine is not successful at treating the illness or slowing the progression of the disease, other treatment options may be considered as well. 


In severe cases of liver disease, a liver transplant may be needed. This type of surgery can be tricky, and it can be challenging to find a donor who is a match. The body cannot function without a liver, so a transplant can be the only option if the liver fails. 

Habits That Support A Healthy Liver 

While some illnesses and diseases affect the liver that can't be avoided, most problems are preventable. Maintaining a healthy lifestyle is essential for optimal health, and there are certain things you can avoid and do to help improve your overall health and protect your liver. Here are a few of them. 

Take Supplements 

If your body is not getting the vitamins and nutrients it needs, the liver may begin to stop functioning correctly. This can lead to serious health problems. Most people get the nutrients they need from the foods they consume, but if you are not eating healthily, you may be lacking specific vitamins. Supplements can be taken to replace the missing nutrients and to help your liver function properly. 

Avoid Alcohol 

Alcohol has a devastating effect on the liver. The body may tolerate an occasional alcoholic drink, but when it becomes a daily habit or when consumed in excess, it can destroy the liver. Alcohol is one of the leading causes of liver disease. It prevents the body from filtering toxins and can cause the liver to swell and stop functioning. Avoiding alcohol will help keep your liver healthy. 

Avoid Smoking 

Smoking can have many adverse effects on the body, and it can cause damage to the liver. The liver filters the nicotine as it travels through the body. Over time, the nicotine can weaken the liver and cause it to stop functioning normally. Reducing smoking can help reduce the adverse effects on the liver, but it's better to avoid smoking at all. 

Reduce Exposure To Toxins 

Our bodies are exposed to toxins every day, and the liver helps filter these toxins, so they do not build up in the body. Anytime toxins enter the body, they will travel through the liver, where they are filtered out. These toxins can also affect the liver by causing swelling and inflammation. It's best to avoid exposure to things that contain these toxins to reduce the number of toxins that go through the liver or build up in the body at one time. 

Avoid Illegal Drug Usage 

Illegal drugs often contain strong chemicals that are filtered through the liver but can cause serious health problems. The more you abuse drugs, the more your liver has to work to filter out the toxins. If you want to protect your liver and improve your overall health, it's best to avoid any illegal drugs. 

Avoid Overusing Medications 

You may be prescribed medication to help improve your health, but the longer you take certain medicines or, the higher your doses, the higher your risk of liver damage. All medications are filtered through the liver and have the potential to harm it. If you are experiencing liver problems and take medications regularly, you may want to talk to your doctor about switching to a smaller dosage. 

What To Do If You Suspect You Have Liver Problems? 

If you think you may have liver problems or any of the symptoms of liver disease, it's essential to make an appointment with your doctor immediately. Your doctor will evaluate your health condition and decide if you need to see a specialist or if they can treat you themselves. Do not put off seeing a doctor, and never try to treat your illness on your own. Liver disease is severe, and the sooner you seek medical attention, the better your chances of finding an effective treatment. 

How To Prepare For Your Doctor's Appointment 

If you are being referred to a specialist for your liver problems or seeing a doctor for the first time, it's essential to be prepared. There are several things you can do to prepare for the appointment. 

Follow Restrictions 

Depending on what your doctor has planned to do at the appointment, you may be given certain restrictions. This could range from not eating and drinking after a specific time to not taking your medication. Follow these restrictions to help make tests more transparent and ensure a more successful appointment and a proper diagnosis. 

Record Your Symptoms 

You will need to be able to communicate your symptoms to your doctor. It might not be enough to say you aren't feeling well or have pain and discomfort. You should try to note when the pain or problems occur and how long they last. You should also note if the symptoms are more severe at certain times of the day or after doing certain things such as eating, changing sitting positions, waking up in the morning, or using the restroom. 

Bring Your Medications 

Your doctor will need to know what medications you are taking as well as the dosage. Sure, they may be able to look them up in your records, but it's much faster for them to have your medicine at your appointment. You can also tell them if you follow the dosage recommendation or take more or less than prescribed. If you are not taking your medication as directed, you should inform your doctor. You can also make a list of medicines and the dosage you take if you prefer to leave your actual medications at home. 

Bring Someone Along With You 

When you get to the appointment, it can be nice to have someone there with you. You might get nervous and need the support of someone you love. Your loved one or friend can drive you if you aren't feeling well after the appointment and will be there to remind you of any questions you might have. They may even be able to speak up and tell the doctor if they notice any changes or symptoms that you may not have seen or may have forgotten about. 

Ask Questions 

You have the right to ask questions at the appointment, and doing so can make you feel better and more confident in the outcome. Your doctor will be happy to answer your questions and address your concerns. You may get nervous or distracted at your appointment, so it's a good idea to write down your questions before you get to the appointment. You may want to take some time the night before the appointment to make a list of things you want to ask. 

Liver Health Detox Products FAQs 

Q: What Does The Liver Do? 

A: The liver is the largest solid organ in the body. It assists with the body's metabolic functions and immune system. 

Q: Why Are Supplements Important? 

A: If your liver is not functioning correctly, it can cause serious health problems. A lack of nutrients and vitamins can prevent the liver from working as it should. Supplements can help keep the liver in optimal health and even improve its function. 

Q: How Do I Take Liver Supplements? 

A: Once you have found a liver supplement that meets your needs, you can follow the directions on the packaging to take it properly. Most supplements are taken orally and should be taken with food. 

Q: Are Supplements Safe To Use? 

A: Yes, in most cases, supplements are entirely safe to take. Before taking any new supplement or medication, it is always best to talk to your doctor. 

Final Word on the Best Liver Supplements 

No matter who you are, caring for your liver is of vital significance to the overall health and function of the body. 

By now, the best liver supplements for detox and cleansing purposes have been researched, reviewed and recommended at great lengths. 

Out of the many dozens of products formulated to optimize liver health and enhance function, these are the top 8 best liver health supplements on the market for sale in 2021: 

It is wise this day and age to lean on the side of caution of making sure the body and especially the liver has ample amounts of nutrients in the form of vitamins, minerals and herbal extracts to utilize for optimal functioning. The review of the best liver support supplements will be updated as more information becomes available in the coming weeks and months. 

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